Many mutants have been isolated which are defective in chromosome segregation. In combination with indirect immunofluorescence to detect spindle and chromosomal proteins, the FISH technique should further advance our understanding of fission yeast chromosome structure and function.
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The recent discovery of a heterochromatin-like structure mediating transcriptional repression at centromeres reinforces the notion that fission yeast centromeres are similar to those of larger eukaryotes. Further characterization of such phenomena will accelerate the genetic dissection of this important chromosomal element.
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The common helical constitution contains nucleosomes, created from histones round which the DNA is wrapped. A hierarchy of upper order of chromosomal structure may well be liable for the law of gene helical buildings expression.
Elements of chromosome structure and function in fission yeast.
The localized condensations of DNA represent chromomeres. Uncoiled buildings occasionally extending from chromomeres, which shape loops, is the results of discontinuities within the commonplace coiling of the DNA within the chromosome. Cotton We are living in an age of ubiquitous genomics.
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